Extensive Darier Disease Successfully Treated with Doxycycline Monotherapy
نویسندگان
چکیده
Darier disease (DD) is a rare dominantly inherited genodermatosis characterized by loss of intercellular adhesion (acantholysis) and abnormal keratinization. DD is often difficult to manage. Numerous treatments have reportedly been used for the treatment of DD, with limited success. Systemic retinoids are considered the drug of choice for treating DD. However, their use is limited by potential deleterious side effects. Considering the recently reported efficacy of doxycycline for Hailey-Hailey disease, an inherited acantholytic skin disorder pathogenetically similar to DD, we report the case of a patient with extensive DD who showed a dramatic response to oral doxycycline monotherapy.
منابع مشابه
Lyme meningo-radiculitis responsive to oral doxycycline therapy in the USA
The spirochete strains that cause Lyme disease are different between the USA and Europe. This leads not only to a variation in clinical presentations, but it was also thought to alter responsiveness to antibiotic treatment. Unlike in Europe, in the USA there are no head-to-head trials of oral and intravenous antibiotics in the treatment of neuroborreliosis. Guidelines from the American Academy ...
متن کاملTreatment of brucellosis: a systematic review of studies in recent twenty years
Background: The treatment of human brucelosis is controversial. The purpose of this study was to search published clinical trial papers to provide a simple and effective treatment in brucellosis. Methods: Many studies on brucellosis treatment in a twenty- year span from 1993 to 2012 were searched in PubMed, Web of Science (ISI), Scopus, Google Scholar, Magiran, Iranmedex and SID. The studies ...
متن کاملLyme carditis with isolated left bundle branch block and myocarditis successfully treated with oral doxycycline
Lyme disease may present with a variety of cardiac manifestations ranging from first degree to third degree heart block. Cardiac involvement with Lyme disease may be asymptomatic, or symptomatic. Atrioventrical conduction abnormalities are the most common manifestation of Lyme carditis. Less common, are alternating right bundle branch block (RBBB) and left bundle branch block (LBBB). We present...
متن کاملRed scrotum syndrome.
BACKGROUND Red scrotum syndrome is a rare and chronic disease affecting males in their second half of life. It is characterized by erythema with sharpborders, no scaling but burning and pain sensations. MAIN OBSERVATIONS We report about two cases treated successfully with either doxycycline and tacrolimus or gabapentine. CONCLUSION For practical purposes we suggest to start treating red scr...
متن کاملTreatment of Tularemia in Patient with Chronic Graft-versus-Host Disease
We describe a case of human tularemia caused by Francisella tularensis subsp. holarctica in a stem cell transplant recipient with chronic graft-versus-host disease who was receiving levofloxacin prophylaxis. The infection was characterized by pneumonia with septic complications. The patient was successfully treated with doxycycline.
متن کامل